I work in the Wish Granting department this summer. I do all of the behind the scenes stuff from scheduling flights to tracking down Dr's faxes. I've seen a lot of kids and a lot of wishes and in the process have learned tons about the organization.
If you have any questions about Make A Wish, the kids, the wishes, or myself (I know my commute has been an interesting topic for some) feel free to ask!
Edit: some people have asked how to take an active role as well. You can find your local chapter and inquire about volunteering and internship opportunities.
I don't want to be on here asking for money, but some people have inquired:
If you have some extra air miles or money, and you're considering a donation - please donate to your local chapter! It's local money going to help local kids, using local services. You can donate air miles, toys, or money. If you want to ensure your donation will be provided for a wish kid, air miles and toys will do that and donated air miles do not expire! And as always, donations are very appreciated and also tax deductible :D