urinesain

My bachelor's is in biology, and I'm a partner in a b&m CBD health and wellness store where we focus very heavily on educating consumers. This question is probably more in depth than any customer would really need to know, but it's just been on my mind.

CBD is believed to lead to increased levels on anandamide (AEA). CBD doesn't bind directly to the CB1 receptor, but is believed to bind to an allosteric site on CB1 as a negative allosteric modulator, which is believed to be responsible for reducing the "high" associated with THC by reducing its binding affinity. I would assume it would have the same effect with anandamide? Is this perhaps how it leads to increased levels of AEA? Either through a feedback loop where the body notices that it isn't binding so it ramps up production? Or due to lack of binding it just naturally leads to increased levels of circulating AEA? Or is the increase in anandamide due to some other process?

I know I went more in depth in explaining my question than I needed to, as I know you already have vastly more knowledge than I do on the subject, but I figured if anyone else found my question interesting that it might benefit them having a bit more information on the background of what my questions pertained to. Also, if I'm wrong with any part of the above, I'd love to be corrected! Learning is probably my most favorite thing. Thank you for taking the time to do this AMA!

Oh my gosh, I feel so silly for forgetting about FAAH! At my store I used hold free weekly lectures (pre-corona) on CBD and how it works in body and I had a whole thing on overactive FAAH and endocannibinoid deficiency syndrome and how treatment resistant migraines, IBS, and fibromyalgia all having common comorbidity with another and that at least one common thread between them all were significantly reduced levels of AEA.

Thank you for taking the time to answer my question, and I feel pretty jazzed that you were impressed by it as well, haha. My undergrad focused primarily on cellelur bio, microbiology, biochemistry and molecular biology so that's where my interest lies. The whole mouse, rat, and human FAAH is really fascinating. Really goes to show how some pre-clinical studies done on rodent models don't always translate as well with humans, but I'm really looking forward to reading the research you posted!