Highest Rated Comments


strawgodargument2 karma

Do you think a moderately calorie restricted ketogenic diet might be able to replicate the results?

I've followed a ketogenic diet since my T2 diabetes diagnosis in September 2015, and have lost 23kg in that time (BMI changed from 33.4 to 25.7). The onset of open diabetes was no more than five years prior, since in 2010 my FBG was just over the border of pre-diabetic (103 mg/dl). In the first eight weeks of the diet I lost 10kg, which is slightly slower than the average weight loss of your subjects on the Newcastle VLCD.

Thank you for your amazing research; it is one of the first pieces of good news I found when researching diabetes on the day of my diagnosis.

strawgodargument2 karma

Thank you for the encouragement!

Your twin cycles hypothesis accounts for how to reverse the beta cell dysfunction in more recently developed T2 diabetes. The two 'handle bars' are positive caloric balance and pre-existing insulin resistance.

Your follow-up advice is to eat at about 2/3rd the previous calories, to mitigate the excessive intake.

What is your thinking on how to mitigate insulin resistance, especially after the weight has been lost? The loss of fat in the liver would surely help mitigate IR, but what about IR in the rest of the body? The two suggestions I see commonly made are to exercise, and possibly to use intermittent fasting. What kind of lifestyle changes do you recommend to mitigate IR in the long-run?