red_concrete

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red_concrete72 karma

A lot to unpack here

There really was not a lot to unpack there. You sell a package of longitudinal measurement of many biomarkers, with no valid justification for why more, nor why these, are better for prediction of disease risk. There is far too much uncertainty. I would be surprised if you obtained any R2 value over 0.15 (the publication you linked up-thread doesn't even report them). You may have confidence in the associations (I can't comment), but that says next to nothing about predictive ability.

We would love to chat more with you to have a critical debate about the scientific underpinnings of our concept.

I'm another guy here, but here you go... An AMA is a perfect venue for such a chat.

red_concrete20 karma

In my circles (medical statistics) that clustering paper was quite widely derided. I wasn't aware anyone considered it seminal. Do you have statisticians on staff that assist you with critical appraisal?