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payne_and_gain4 karma

a minor correction (you probably won't read it, but i want the record to be correct): tau is not found in huntington's. tau and a-beta are both found in alzheimer's, tau as intracellular tangles (that are eventually thought to propagate synaptically) and a-beta as extracellular plaques. huntingtin is the protein that is mis-aggregated in huntington's disease.

payne_and_gain3 karma

well i was referring more to the appearance of symptoms rather than the progression of the disease itself. sorry for the confusion.

payne_and_gain3 karma

wow you actually read this! anyway, just wanted to say this was a great ama.

payne_and_gain1 karma

i think anyone who answers that questions completely will most definitely win the nobel prize.

payne_and_gain1 karma

i believe cjd is also extremely aggressive and rapid in progression, whereas alzheimer's progresses over the course of 10+ years (there are rare variants that are more aggressive). a crude (but unfortunately, mostly true) saying about cjd that neurologists sometimes make is "if the patient doesn't come back for a follow-up in six months, it was most likely cjd"