markvdr

In relation to your 2010 paper "Engineering a Better Way to Heal Broken Bones", led by Matthew Murphy: What importance do you assign the physical environment in promoting MSC differentiation towards an osteogenic lineage, specifically on the nano and micro-scale level? That is, in relation to the chemical environment, how important is the physical or mechanical environment that the cell interacts with, ie. stiffness, smoothness, nano/micro-structure?

Also, is the fracture putty used clinically yet, and if not do you see that as a possibility? If scaffolds preloaded with cells perform significantly better, what sources would these cells be taken from?

If you're the David Bricker I think you are, then might I say Go Blue! (Sorry, I creep super hard.)

No we didn't; I'm currently attending. I did a quick google of your name, and your LinkedIn profile has your education history.

Check out this recent paper into that exact question. I'm pretty sure the journal is open access too, so you should be able to see it for free. If not, let me know. Plenty of groups out there are interested in post-MI fibrosis, or cardiovascular fibrosis in general. Things are still a little ways away from seeing clinical use, but the groundwork research is being done right now.