larkasaur

From Food Allergy: From the of Loss of Tolerance Induced by Exclusion Diets to Specific Oral Tolerance Induction

The prevalence of food allergy and anaphylaxis in children is reported to be increasing in recent years. Evidence suggests that exposure to large doses of antigen might produce a suppression of the specific IgE response, so that the continuous contact with high doses of antigens favours the maintenance of tolerance In the same way loss of contact with allergen in children with specific IgE reactivity may favour a loss of tolerance with development of systemic reactions, while a progressive new contact with allergen may favour a specific tolerance induction. We hypothesize that widespread and uncontrolled use of elimination diets for atopic dermatitis may have played a role in the increase of allergy and anaphylaxis.

Do you think this is true? The authors think exclusion diets (excluding some food allergens) may be part of the reason why food allergies are increasing, but they seem to blame specifically exclusion diets for atopic dermatitis. How common is it for children to be put on exclusion diets because of atopic dermatitis?

I like to call allergy the “Rodney Dangerfield” of medical diseases because we “don’t get no respect.”

Why do you think this is?

People can also have non-celiac wheat/gluten sensitivity. See Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review.

The comparison between patients suffering from NCWS and presenting with irritable bowel syndrome (IBS) and controls with IBS not due to NCWS showed that NCWS was characterized by: a personal history of food allergy in the pediatric age (0.01), coexistent atopic diseases (0.0001), positive serum anti-gliadin (0.0001) and anti-betalactoglobulin (0.001) antibodies, positive cytofluorimetric assay revealing in vitro basophil activation by food antigens (0.0001), and a presence of eosinophils in the intestinal mucosa biopsies (0.0001).