Highest Rated Comments

kelny8 karma

Let me get this straight: So the first theory posits that there must be some change in environment that acts as a catalyst, while the second suggests that formation of amyloid is essentially a stochastic process where in the unlikely event that a sufficient seed forms you get positive feedback?

Do you favor one model over the other? Does amyloid form in vitro? If so, with what kinetics? It seems to me the two models imply quite different reaction kinetics.

Edit: Thinking about theory 1 more I suppose it doesnt have to be a change in the activation barrier like I was imagining, but could be extremely high concentration of protein. What sorts of 'changes in environment' do people imagine?