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ifmb195 karma

When darkly pigmented people get extensive vitiligo that does not responds to treatment, one option is to permanently depigment the remaining skin using monobenzyl ether of hydroquinone (MBEH). This is probably what MJ did so as to not have to use makeup daily.

ifmb63 karma

Since you have a mosaic defect, you would not require gene replacement. A biopsy of your "healthy" skin could be expanded in culture and grafted onto your more affected skin. This treatment approach is not standard of care, but is being tried in research settings.