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i_am_not_a_pumpkin8 karma

What does 'inmune checkpoints' mean and how can they be controlled through antibodies? I know about antibodies used for the opposite: to 'switch off' the immune system for example in cases of autoimmune disease. But how does one make it stronger against cancer?

Also, can we use polyclonal antibodies as therapy? Or even make our body naturally generate antibodies to help the process? I understand that we already create antibodies against cancerous cells, but that those cells have the power to attenuate the immune response. Could be build immunization against this attenuation?