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How often do you get winners?

While humans are generally quite adaptable, a lot of behavior is still limited by our biology. In particular, we exhibit many self destructive tendencies that, while there exists interventions for individuals on a case by case basis, are difficult to affect or prevent at a societal level.

When we inevitably obtain the ability to engineer our own biology, is there anything in particular you'd like to change? Should we change anything at all?