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Preach /u/Sausage_Wallet

David Nichols spoke about why endogenous DMT is unlikely to have any physiological effect at last years psychedelic science conference. He's probably the best qualified entity of any dimension to talk about this topic:

https://www.youtube.com/watch?v=YeeqHUiC8Io

Robin Carhart-Harris, who's currently the most influential researcher in the field and proposed both the entropic brain hypothesis and the REBUS model, is "no comment" on whether he's ever used psychedelics. He neither admits or denies it and has said "It's a lose-lose situation" because admission or denial will lead to biased perception of his research from different sociocultural groups.

He's trying to protect his research from other people's bias, not his own.

How important is it to develop novel therapeutic techniques, or even environments, for use with psychedelics?

How hard will it be to quantify the therapeutic value, or dangers, of psychedelics in relation to different therapies and therapeutic environments?