denzil_holles371 karma2016-03-07 17:51:07 UTC
Those patents are expired. Manufacturing good lego parts is difficult.
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denzil_holles18 karma2019-08-05 02:56:24 UTC
Shedded endometrium can be reabsorbed into the peritoneum/myometrium, most likely through macrophage mediated consumption of apoptotic and necrotic cells and blood. This occurs in women with endometriosis. Resorption of menses is physiologic in most mammals (only humans and 9 other mammals shed their menses).
Sepsis wouldn't occur since the endometrium would have been sterile (the uterus is sterile, only the vaginal canal is colonized by flora). Sepsis is mediated by a inflammatory reaction to bacterial products (eg LPS).
Nature Reviews Endocrinology volume10, pages261–275 (2014).
Bioessays. 2012 Jan; 34(1): 26–35.
denzil_holles14 karma2019-08-05 00:43:29 UTC
To create a vaginal canal for OP, you would need a team consisting of a pediatric gynecologist, urologist, and pediatric plastic surgeon that specialized in the pelvis, also a modern OR and a anesthesiologist. Outside of a major urban academic center, you are unlikely to find such expertise.
Often MtF and FtM transition surgeries require a similar team (GYN + urology + plastic surgery). These aren't easy, run of the mill surgeries that a general surgeon could do in a community or rural hospital.
denzil_holles12 karma2019-08-05 00:41:09 UTC
Probably de novo; Mullian agenesis (or in OP's case, vaginal agenesis) are multifactorial inheritance so genetic studies aren't useful.
denzil_holles6 karma2019-06-18 21:01:27 UTC
The pathophysiology of migraine is not fully understood. Different aspects contribute to the development and severity of migraine, such as
Most drugs target vasodilation:
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