curlyhairedsheep

As a Nobel laureate, you clearly benefited from the glamour publications and now have less to lose while walking away from them. What do you suggest to young postdocs who are frustrated with the current system but are concerned about future job prospects being contingent on publication in these luxury journals? How do your current postdocs feel about this decision and their future career prospects?

How do you define "important"? At the end of the day, that's the real gatekeeper - the trend-based biases toward what is sexy science at that moment. There's lots of meaningful science that isn't trendy, won't get you news coverage today, but yields a better understanding of biological systems that may give rise to something more "exciting" in the future.