Yiping07

Hi Professor Hussell, Professor Cruickshank, Professor Grainger, I am Yiping, a PhD student in mathematics. I am interested in the models in immune system and I have several questions about immunity of COVID-19. 1. Is the inflammation(including cytokine storm) the main reason that leads to COVID-19 death? 2. What’s the cause of cytokine storm? Is this because innate immune cells keeps secreting those cytokines? 3. Is lymphopenia associated with cytokine storm? 4. How do our body regulate the pro-inflammation cytokine and anti-inflammation cytokine? If the immune cells secret anti-inflammation cytokine, does it mean it’s going to shut down our immune defences? Thank you in advance! Kind regards. Yiping

Thank you so much!!

Hi, thank you for all the work you have done! I was wondering if we have enough information to model the within-host immune response against Covid-19 mathematically? And if so, what kind of information do you expect mathematical models to answer? Thank you very much!

Thank you so much for the information!