Your explanation of Toxo encephalitis in HIV patients confuses me a bit. Are T-cells present in neural tissue? Otherwise if Toxo passes the BBB, how would the lack of adaptive immunity predict a worse outcome since there are only innate immune cells (microglia) in the brain? This may be outside the scope of your study, but it's interesting nonetheless.
Also, were you responsible for sacrificing the mice from your study upon its conclusion? If so, how did you handle it (physically and emotionally)?
WellThatsAllThen3 karma
Your explanation of Toxo encephalitis in HIV patients confuses me a bit. Are T-cells present in neural tissue? Otherwise if Toxo passes the BBB, how would the lack of adaptive immunity predict a worse outcome since there are only innate immune cells (microglia) in the brain? This may be outside the scope of your study, but it's interesting nonetheless.
Also, were you responsible for sacrificing the mice from your study upon its conclusion? If so, how did you handle it (physically and emotionally)?
Good luck on your defense.
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