Upbeat_Pangolin_5929

I’m still a nervous flyer, despite having to fly all over the world as part of my job. Is there anything that you can share with me that might calm my nerves, especially during severe turbulence?

I spend 55% of my time traveling for work, and this involves flying all over North America, Europe, and Asia. I have experienced “severe turbulence” once, as confirmed by the pilot. It was terrifying, and has pretty much ruined my flight experiences ever since. This was on an A320 flying from California to Hawaii. Even the pilot sounded scared.

It was a combination of a feeling of weightlessness immediately followed by a large crash that felt like an impact, over and over again. My thoughts immediately go to an “I’m 100% going to die” mode and I fall into a state of what’s probably a panic attack. People were screaming, people were crying, stuff was flying everywhere… it’s pretty much my worst nightmare.

Interestingly, I tried completing a sudoku puzzle during turbulence once. I didn’t find it as bad.

Stem cell research scientist here. I’ve seen some questions related to CRISPR, and I’m guessing that gene editing approaches must be being looked at for this disease (with AAV vectors). However, I wonder if anyone is looking into lineage conversion / direct programming of the bone? This is relatively new technology that can already be done in the dish - literally the direct conversion of one cell type into another using small molecules. Up until this point, I hadn’t thought of a practical application for it in vivo, but this absolutely would be.