TechnicalVault

It’s amazing what they’ve managed to retrofit into the stations already considering how most of them were built either by the Victorians or very early 1900s by several different companies. Are there any interesting bits of “old” that you get to see as a driver that the rest of us don’t?

Interesting, Ivacaftor and the combination ivacaftor/lumacaftor (Orkambi) are cell level treatments rather than lung specific treatment, so they should work on all regions where your funky chloride channels mess with you not just your lungs. Ivacaftor increases your chloride channel activity and lumacaftor bends F508 CTFR into a shape where it works. It's really the mutations you have that affects how well they work. My friend's daughter has 508 and a much more rare splice site mutation so she's stuck until she's 6 and VX445 is licensed for 6-12.

Aye we never built the express lines running parallel to the local lines that you see on subways like NYC (there was a plan but if never panned out, I believe this was the original plan for the deep level shelters). Thus there is no way for the trains to get around work crews on the track.

I did hear that fitting the doors seriously change the air flow (for the better) but I imagine that would require some heavy planning to retrofit.

Since the Statute of Westminster in 1931 (and a couple of more recent items of caselaw) that is no longer the case. The Crown in the right of Canada is separate to the Crown in the right of the United Kingdom of Great Britain and Northern Ireland.