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SoCalTiger1347 karma

Is there a potential risk in using a self-replicating vaccine? Specifically, is there a risk that there could be "runaway" replication? What would that look like and what would the result be?

Alternatively, could this be a benefit if it managed to replicate at low levels for a long time? Not sure if this is even a possibility but would this provide a longer term of protection if it happened?