Highest Rated Comments


Nick9933236 karma

IIRC, the energy binders of a pod racer could provide the same paralyzingly effect, but without any of the unfortunate negative side effects -- like radiation poisoning and slow...agonizing...death.

While I don't think there is a ton of research on the subject, I did watch a documentary that recounted the story a man whose tongue accidentally got caught in the path of the energy binders (EBS) used in the most powerful pod racer ever built. While one would think such an accident would almost assuredly result in instant death, it instead resulted in a clinical case of facial paralysis similar to the one you described. Not only did this man not die from radiation poisoning, but he was also able to go on to become a highly decorated war hero and one of the most influential and respected senators the galactic republic had ever known -- the best part was because of his incident with the EBS he was able to maintain his youthful, vibrant complexion throughout his life!

Now some people speculate that was likely because he was a Gungan, who are a species known throughout the galaxy for their intelligence, beauty and seemingly miraculous ability to defy senescence, but any real scientists who is familiar with Senator Binks would agree with me and they would also undoubtedly agree that sticking your face in between the energy binders of a high octane pod racer is the next big thing. The real fountain of youth.

Nick993365 karma

In many professional sports 'flopping' is a hotly debated topic. How is flopping going to be handled at this year's puppy bowl?

Nick993348 karma

Being a delivery driver was probably my favorite job to date. Not did I not have to worry about being around my coworkers and boss for most of my shift, but my boss also particularly liked me for some reason and would costany schedule me for the busiest times and give me the best routes (i.e. most large homes in the richer area). I’d consistently make $25+/hr and not really worry about shit other than getting the pizza to where it needed to be.

4.5/5...I’d reccomend as a part time job

Nick993339 karma

How does it end up in pet food? If you know the answer to that, please let me know!

Pentobarbital while it is true that it is most famously used as an euthanasia agent, it does have additional FDA approved usages in both humans and veterinary medicine, namely as both a sedative and anesthetic induction aide.

Quickly checking the pharmacodynamics of the drug, and many of its more popular therapeutic cousins, reveal that all level of therapeutic barbituate usage will result in extremely high levels of plasma protein binding, which also predicts high levels of tissue sequestration. Experiments confirm this suspicion, and in fact, even slow on-set, larger barbituates like phenobarb will be encountered in all visceral tissues in high concentrations if the animal was being treated chronically, or began treatment with loading dosages as would be recommended with these types of drugs. All of this lends credit to the theory that if pentobarb was used on a food animal, whether for euthanasia or different purposes, we would expect it to remain in the tissue following the death of the animal unless special precautions were taken.

Now I also mentioned phenobarbital in there as well, because we must take into consideration any and all possible metabolic and food processing reactive products we might expect to encounter if an animal was on this medication or any other barbital for that matter.

The basic organic chemistry makes up of pentobarbital compared to other popular barbituates like phenobarbital and primidone reveal high levels of homology.

Even though there is no data that would suggest any barbiturate gets actively converted into pentobarbital in situ, there are a great number of conditions that can cause active barbituates to form from the common first pass hydroxylated metabolites (e.g. simple metallic reduction and weak organic acid are enough to produce potent barbituates from barbituric acid +/- inactive barbiturate enantiomers sometimes).

In fact, while they aren't directly active, many barbituates do theoretically get metabolized into some very closely related isomeric and enantiomeric products after they undergo both types of first-pass hepatic metabolism. This complicates the issue significantly because now we have to be aware of the possibility that any barbiturate drug could possibly be a meat-byproduct contamination, and that all of these, under the right conditions, might show up specifically as pentobarb despite no history of pentobarbital usage in any of the contaminated products.

Based on this, I would definitely predict some barbiturate being used therapeutically somewhere along the supply chain as the primary cause of this problem. Whether the contamination was the direct result of pentobarb usage or the result of an indirect secondary barbiturate that then underwent one, or a series, of reactions that turned the metabolites into pentobarbital or a pentobarbital isomer, the chemical properties and pharmacological dynamics of this class of compounds certainly are consistent with this hypothesis.

Of course, that doesn't allow us to completely rule out less likely possibilities such as: caches of expired or mishandled barbiturate agents that somehow polluted drinking water reserves. Or contaminated production equipment that was used to produce the food, or even the malicious intention of someone involved in the production can't be ruled out.

Out of all of these hail mary predictions, I admit it wouldn't that unlikely to learn that there were barbiturate drugs in the drinking supply. With that said, these compounds are not among the drugs the EPA has labeled as the most common pharmaceuticals and EDC's present in public drinking supplies. Any chance for this to occur would also require extremely heavy contamination which is unlikely just based on how small the dosages are and how little is legally allowed to be maintained in singular areas because of its status as a 'killer' injectable agent.

That is my own personal not professional perspective on where this might have come from.

Source: Current Vet student W/ BS in Chemistry

Nick993313 karma

tumescent

Nice..