FlavaFlavivirus

They should have a government-only service called Federal FedEx Express

First, I would like to thank you for moving this through the courts. As a microbiologist, I see how IP laws stifle innovation on a daily basis.

In terms of the ruling, it states that cDNA is patentable. I am afraid that this part of the decision could be problematic. For instance, if a RT-PCR assay were developed for the detection of a specific RNA species, would the cDNA sequence, and hence the RNA sequence be patentable? If so, is it the entire replicon that is patented, or only the primers and probe? Could you just design a new set of primers and probe to get around it?

Hi Stephen. I am a microbiologist who develops treatments for tropical diseases.

Looking through the paper, I saw 2 major issues with this vaccine:

1. Patients were vaccinated with cryopreserved plasmodium, up to 6 times over the course of several months. How do you plan on dealing with delivery issues relating to cold storage in Africa and other developing regions? Also, vaccine compliance might be weak, as several doses are required to induce protective immunity. How do you plan on immunizing thousands of people in outlying areas with several doses per person?

2. There seemed to be an unusually large number of adverse events associated with this vaccine. Of 57 vaccinees, there were many mild AEs, and there was a severe AE. Do you really think this will gain approval in the age of the litigation attorney?

I fully support what you are trying to do, but feel that this paper is receiving an undue amount of press for a not particularly promising vaccine.

I have worked with both, but am currently using vaccine strain Yellow Fever.