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Cic3ro1 karma

I live on the upper east coast of the US and was told by an epidemiology professor that the flu virus travels up the coast over the course of the Winter and often mutates by the time it gets to this area. He suggested getting the flu vaccine either twice (at the season start and middle) or one a little later (early Dec, Late Nov.) in the season. Is there any truth to this? How often is the virus likely to mutate over the course of the season?