Adalmodus

My lifegoal is to modify a single gene, a monogenic defect so. How's realistic to do it with CRISPR? I mean my only true fear is the Immune system going nuts, is that an issue? (It's a single organ I'm talking about, not a gene involving too much functions, just an enzyme reduced by 70% of its power)

Thank you, my only concern was that as the organ in question is the Liver. It should be easy to edit, 3 mins in the bloodstream and I would be set. Shit...I feel so pathetic as it's not a life treathening disorder but I must win Nature. Before I die I must settle this.

I was reading about a new "Crispr" called HiFi Crispr, could at least mitigate the problem about Off-Targets...still I'm scared about a liver failure if it fails...4 days of agony before sure death are not something I'm looking forward. Time passes and I hope precision tools would develop too, ty for the reply!