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Hi Mr Gates.

I work in health-care in South Africa and I just want to say thank you for the work that your foundation has been doing for HIV research here. Your willingness to help those who have less than you is something that I truly admire and aspire to.

My question is how do I feel like I'm doing enough? With all the pain and suffering that I see everyday, it's hard to feel like I am actually making a difference in the grand scheme of things. How do you deal with feeling like it's a never ending struggle to actually make a difference and help people?

Edit: I've noticed a lot of people giving gold and silver in this ama. Please consider donating the money instead to worthy causes. I'm sure Mr Gates would appreciate that a lot more. Thank you. And a big thank you to everyone for their kind words, I really do appreciate it.