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First, let's clear up what an acronym is. It is an initialism that is pronounced as a word. I don't think I've ever heard anyone pronounce "SOB" as a word. People pronounce the letters /es-oh-bee/. This makes SOB an initialism. NASA /nas-uh/ is an acronym, an initialism pronounced as a word.

Because the name of letter S is pronounced with a leading short /e/ vowel sound, we should say and write "He really is an SOB".

English has a specific adjective order that native speakers learn at an early age. Language learners often have a difficult time learning this order at an adult age. Here are some resources to help clear this up.

https://www.grammarly.com/blog/adjective-order/

https://dictionary.cambridge.org/us/grammar/british-grammar/adjectives-order

Use "less" with uncountable nouns and "fewer" with countable nouns. Examples: less water and fewer people.

Wouldn't the world be a better place if we could all agree that the
the decimal point is only to be used for decimals (0.715) and the comma for
separating thousands (7,150)?

I've actually seen the vocative comma used in that phrase but it is extremely rare. The lack of the vocative comma gets to me too. xD